Oxymetholone (also known as anapolon or anadrol) is a very drastic synthetic steroid, 17-alpha-alkylated modification of dihydrotestosterone. It was developed for the treatment of osteoporosis and anaemia, as well as to stimulate muscle gain in malnourished and debilitated patients. Oxymetholone has been approved by the American Food and Drug Administration (FDA) for use in humans. Later there where created non-steroidal drugs that effectively could treat anaemia and osteoporosis; because of this anapolon lost his popularity and by 1993 Syntex decided to cease the production of the drug, as well as other manufacturers did.
Then we have the female virilization effects; virilization referring to the promotion of masculine traits in women; such effects can include body-hair growth, a deepening of the vocal chords and clitoral enlargement. For this reason, staying in the time frame of use mentioned in the benefits section is extremely important, and low doses should be used as well. If you do this, most women will be fine, but if virilization symptoms begin to show for any reason all hope is not lost. If symptoms begin to show, you should discontinue use at their onset, and if you do they will fade away rapidly. If they are ignored, this is where a problem will occur, and you may be stuck with them for the rest of your life.
Although I am usually not inclined to posit speculations on why a particular drug does or doesn't do something, in this case I will. Im guessing that the higher doses of Anadrol cause enough appetite suppression (at least anecdotally) to make eating rather difficult. It can also increase insulin resistance and glucose intolerance (5). This has the effect of making macronutrient absorption more inefficient, and could also be a factor in reducing gains when the dosage goes over 100mgs/day. Unfortunately, Anadrol also has a reasonably profound effect on your body's natural hormonal system, on par with most other oral steroids , but not as bad as most injectables, and its certainly not as harsh on your lipid profile as many anabolics are