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Signs of liver damage are lethargy, stomach pain, jaundice, edema especially in the legs or ankles, etc. I felt great all the time on the orals and wanted to stay healthy. I don't think it's worth risking your health to push onwards past 4 weeks for harsher orals like anadrol unless you truly are competing in a competition or something. If bodybuilding is your life and how you get paid, like Rich Piana, then you can take 150 mg anadrol ED for 20 weeks like he does. I still don't think it's worth it for him to do that, I really don't think he NEEDS it for that long compared to how many other roids he takes
Although I am usually not inclined to posit speculations on why a particular drug does or doesn't do something, in this case I will. Im guessing that the higher doses of Anadrol cause enough appetite suppression (at least anecdotally) to make eating rather difficult. It can also increase insulin resistance and glucose intolerance (5). This has the effect of making macronutrient absorption more inefficient, and could also be a factor in reducing gains when the dosage goes over 100mgs/day. Unfortunately, Anadrol also has a reasonably profound effect on your body's natural hormonal system, on par with most other oral steroids , but not as bad as most injectables, and its certainly not as harsh on your lipid profile as many anabolics are