Neural injections of Bromodeoxyuridine (BrdU) were applied to males of both groups to test for neurogenesis . Analysis showed that testosterone and dihydrotestosterone regulated adult hippocampal neurogenesis (AHN). Adult hippocampal neurogenesis was regulated through the androgen receptor in the wild-type male rats, but not in the TMF male rats. To further test the role of activated androgen receptors on AHN, flutamide , an antiandrogen drug that competes with testosterone and dihydrotestosterone for androgen receptors , and dihydrotestosterone were administered to normal male rats. Dihydrotestosterone increased the number of BrdU cells, while flutamide inhibited these cells.
It shall be noticed, that in men, approximately 5% of testosterone undergoes 5α-reduction to form the more potent androgen, dihydrotestosterone (DHT), also known as androstanolone. From another side approximately % of testosterone is converted into estradiol (the primary female sex hormone) by aromatase an enzyme expressed in the brain, liver, and adipose tissues. Hence, don`t forget to take precautions to avoid respective side effects. Thereof we recommend to perform blood works and take aromatase inhibitors on cycle (if required, anastrozole preferably) and SERMs (clomifene, toremifene) during post cycle therapy (PCT).
Anabolic steroid implants are allowed for veterinary use. But if someone diverts this for use in humans, it will be deemed as a distribution of a Schedule III drug leading to prosecution. The law on trenbolone differs in other countries. For instance, in Canada it is a Schedule IV drug. In Canada, all anabolic steroids are classified as Schedule IV drugs. In the UK, anabolic steroids are classified as Class C substances. Their possession can lead to a 2 year jail term, while their production and supply can lead to a 14 year jail term. But many countries do not have strict laws. In some places, you can even buy it over the counter.