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The solution is prepared by grinding the pellets and adding that to a solution of DMSO . The solution of DMSO , prepared with equal volumes of water . Increasing the proportion of Dimethyl sulfoxide in the solution could increase absorption but is not recommended due to severe skin irritation and skin damage . Common side effects include itching and rashes at the application site . The degree of irritation increases as the concentration of DMSO is increased . Individuals who have very sensitive skin may experience greater discomfort .