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Ralaniten acetate (developmental code name EPI-506 ) is an experimental nonsteroidal antiandrogen (NSAA) which was developed by ESSA Pharmaceuticals and was under investigation for the treatment of prostate cancer . [1] [2] It was a successor of EPI-001 and targets the N-terminal domain (NTD) of the androgen receptor (AR). This mechanism of action is believed to allow the drug to block signaling from the AR and its splice variants . [3] [4] EPI-506 is a derivative of bisphenol A [5] and a prodrug of ralaniten (EPI-002), one of the four stereoisomers of EPI-001. [6] The drug reached phase I / II prior to the discontinuation of its development. [1] It showed signs of efficacy in the form of prostatic specific antigen (PSA) decreases (4–29%) predominantly at higher doses (≥1,280 mg) in some patients but also caused side effects and was discontinued by its developer in favor of next-generation AR NTD inhibitors with improved potency and tolerability . [7]

Trenbolon w tabletkach

trenbolon w tabletkach

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