The station is an international transport hub, handling services to Germany ( Munich , Bavaria- Bohemia RE (Regio-Express) services, and EuroCity / EuroNight services to Berlin , Dresden and Hamburg ), Poland, Slovakia, Austria, Hungary, Switzerland, the Netherlands, Serbia, Russian Federation, Ukraine and Croatia in summer. Services are operated by express trains, and also by ČD Class 680 Pendolino . Services to Moravia, Silesia, Slovakia and Poland are also operated by open-access train operators LEO Express , RegioJet and Arriva .
4 days – Start in and around Rome . Explore the museums in the historic center, take a food tour , explore calmer Trastevere and just soak up the Eternal City.
3 days – Head north to Florence . Use the city as a base to explore the city itself, with a day trip to Siena in the heart of Tuscany and another day to see the famous tower in Pisa (if you are so inclined).
2 days – Take the train to Bologna . Walk the markets of this university city and hunt your favorite Apertivo place.
4 days – Finally head to Venice to get lost in the canals. Check out Murano and Burano nearby.
1 day – Take the train back to Rome and spend your last night if you have an early morning flight out. Alternatively see if Milan has a flight that might be better.